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Publikationer

Precision diagnostics: moving towards protein biomarker signatures of clinical utility in cancer

Carl A. K. Borrebaeck. Nature Reviews Cancer (2017) doi:10.1038/nrc.2016.153. Published online 03 February 2017

Klicka för att läsa artikeln.

Technical Advances of the Recombinant Antibody Microarray Technology Platform for Clinical Immunoproteomics

Payam Delfani, Linda Dexlin Mellby, Malin Nordström, Andreas Holmér, Mattias Ohlsson, Carl A. K. Borrebaeck, Christer Wingren. PLOS ONE. July 2016.

Antibody array generation and use

Borrebaeck, CAK, and Wingren C. Meth. Mol. Biol 2014, 1131, 563-57

Modelling the benefits of early diagnosis of pancreatic cancer using a biomarker signature

Ola Ghatnekar, Roland Andersson, Marianne Svensson, Ulf Persson, Ulrika Ringdahl, Paula Zeilon and Carl A.K. Borrebaeck
Intl Journal of Cancer 2013 (Abstract)

Serum proteome profiling of pancreatitis using recombinant antibody microarrays reveals disease-associated biomarker signatures.

Sandström A, Andersson R, Segersvärd R, Löhr M, Borrebaeck CAK, Wingren C
Proteomics – Clin Appl, 6:9-10, 486–496 (Abstract)

Design of recombinant antibody microarrays for urinary proteomics

Kristensson M, Olsson K, Carlson J, Wullt B, Sturfelt G, Borrebaeck CAK, Wingren, C. Proteomics – Clinical Applications, 2012, 6, 291-296.

Design of recombinant antibody microarrays for membrane protein profiling of cell lysates and tissue extracts.

Dexlin-Mellby, L., Sandström, A., Antberg, L., Karlsson, J., Hansson, SR., Borrebaeck, CAK., Wingren. C.  Proteomics, 2011, 11, 1550-4.

Recombinant antibodies for the generation of arrays.

Borrebaeck, C.A.K. and Wingren, C. Meth. Mol. Biol.. 2011, 785, 247-62.

Design of recombinant antibody microarrays for complex proteome analysis: targeting of complement proteins.

Ingvarsson, J.; Larsson, A.; Sjöholm, L.; Truedsson, L.; Jansson, B.; Borrebaeck, C. A.K. and Wingren, C.  J. Proteome Research. 2007, 6, 3527-3536.

Design of recombinant antibody microarrays for complex proteome analysis: choice of sample labelling-tag and solid support.

Wingren, C., Ingvarsson, J., Dexlin, L., Zul, D. and Borrebaeck, CAK.  Proteomics. 2007, 7, 3055-3065.

Microarrays based on affinity-tagged scFv antibodies: sensitive detection of analyte in complex proteomes

Wingren, C., Steinhauer, C., Ingvarsson, J., Persson, E, Larsson, K., & Borrebaeck,C.A.K. Proteomics. 2005, 5:1281-1291.

High-throughput proteomics using antibody microarrays.

Wingren, C., Borrebaeck, C.A.K.  Expert. Rew. Proteomics 2005, 1, 358-364.

Recombinant antibody microarrays: a viable option?

Wingren, C., Ingvarsson, J., Lindstedt, M., & Borrebaeck, C.A.K. Nature. Biotechnol. 2003, 21, 223.

Design of high-density antibody microarrays for disease proteomics: key technological issues.

Borrebaeck, C.A.K. and Wingren, C.  J. Proteomics. 72, 928-935.

Posterpresentation: Diagnosis of early stage pancreatic ductal adenocarcinoma using a serum biomarker signature

Linda D. Mellby, Andreas P. Holmér, Julia S. Johansen, Christer Wingren, Børge G. Nordestgaard, Stig E. Bojesen, Christopher Corless, Breanna I. Mitchell, Brett C. Sheppard, Rosalie C. Sears, och Carl A.K. Borrebaeck

IMMray™ PanCan-d posterpresentation vid the 49th Meeting Of The European Pancreas Club (EPC), Budapest, Ungern, 28 juni – 1 juli 2017

Klicka här för att läsa postern i sin helhet (PDF) (på engelska)

Plasma protein profiling in a stage defined pancreatic cancer cohort – Implications for early diagnosis

Anna Sandström Gerdtsson, Christer Wingren, Helena Persson, Payam Delfani, Malin Nordström, He Ren, Xin Wen, Ulrika Ringdahl, Carl A.K. Borrebaeck, Jihui Hao. Molecular Oncology, 2016

Poster presentation: Early-stage diagnosis of pancreatic cancer offers opportunity to improve patient survival

Linda Mellby, Andreas Holmér, Julia S Johansen, Christer Wingren, Christopher Corless, Brett C Sheppard, Paige Rosenthal, Stig E Bojesen, Breanna L Mitchell, Børge G Nordestgaard, Rosalie Sears, and Carl AK Borrebaeck

IMMray™ PanCan-d poster presentation at the International Symposium on Pancreatic Cancer in Glasgow, UK, June 9-12 2016

Click here to read the complete poster (PDF)

A multicenter trial defining a serum protein signature associated with pancreatic ductal adenocarcinoma

Sandström Gerdtsson A, Malats N, Säll A, Real F, Porta M, Skoog P, Person H, Wingren C, Borrebaeck CAK. Int. J Proteomics. 2015

Serum protein profiling of pancreatitis using recombinant antibody microarrays reveals disease-associated biomarker signatures.

Sandström, A., Andersson, R., Segersvärd, R., Löhr, M., Borrebaeck, CAK., and Wingren C.,  Proteomics – Clinical Applications. 2012, 6, 486-496.

Identification of serum biomarker signatures associated with pancreatic cancer.

Wingren C, Sandström A, Segersvärd R, Carlsson A, Andersson R, Löhr M, Borrebaeck CAK Cancer Research, 2012, 72, 2481-2490.

Detection of pancreatic cancer using antibody microarray-based serum protein profiling.

Ingvarsson, J., Wingren, C., Carlsson, A., Ellmark, P., Wahren, B., Engström, G., Harmenberg, U., Krogh, M., Peterson, C., and Borrebaeck, C.A.K., Proteomics. 2008, 8, 2211-2219

Grading breast cancer tissues using molecular portraits.

Olsson, N., Carlsson, P., James, P., Hansson, K., Malmström, P., Fernö, M., Ryden, M., Wingren, C., and Borrebaeck, CAK.,  Mol. Cell. Proteomics. 2013, 12, 3612-3623.    

Molecular serum portraits in patients with primary breast cancer predict the development of distant metastases.

Carlsson, A., Wingren, C., Kristensson, M., Fernö, M., Olsson, H., Peterson, C., Borrebaeck, CAK.  Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 14252-7.

Serum proteome profiling of metastatic breast cancer using recombinant antibody microarrays.

Carlsson, A., Wingren, C., Ingvarsson, J., Ellmark, P., Baldertorp, B., Fernö, M., Olsson, H., and Borrebaeck, CAK.  European Journal of Cancer. 2008, 44, 472-480.

Identification of plasma protein profiles associated with risk groups of prostate cancer patients.

Nordström M, Wingren C, Rose C, Bjartell A, Becker C, Lilja H, Borrebaeck CAK.  Proteomics Clinical Applications, 2014, 8, 951-962.

Recombinant antibody microarray for profiling of the serum proteome of SLE.

Borrebaeck, CAK, Sturfelt G., and Wingren C.  Meth. Mol. Biol 2014, 1134, 67-78.

Multiplexing of miniaturized planar antibody arrays for serum protein profiling – biomarker discovery in SLE nephritis.

Petersson L, Dexlin-Mellby, L., Bengtsson, A.A., Sturfelt, G., Borrebaeck CAK, Wingren C.  Lab on a chip. 2014, 14, 1931-1942.

Design of recombinant antibody microarrays for urinary proteomics

Kristensson M, Olsson K, Carlson J, Wullt B, Sturfelt G, Borrebaeck CAK, Wingren, C. Proteomics Clinical Applications, 2012, 6, 291-296.

Antibody microarray-based serum protein profiling of systemic lupus erythematosus and systemic sclerosis.

Carlsson, A., Wuttge, DM., Ingvarsson, J., Bengtsson, A., Sturfelt, G., Borrebaeck, CAK., and Wingren, C. Molecular and Cellular Proteomics, 2011, 10:M110.005033.

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