Publications
Poster: IMMray® PanCan-d Blinded Validation Study
Thomas King, Arash Zandian, Payam Delfani, Veronika Sjöberg, Randall Brand, Arto Kokkola, A. James Moser, Genesis Perez-Melara, Corinne DeCicco, Alfredo Carrato, María E. Castillo-Sánchez, Julie Earl, Aimee L. Lucas, Jan Persson, Daniel Chung, Madeline Friedman, Ava Siegel, Bryson W. Katona, Bárbara Luna-Sánchez, Irene Patricia Amil-Casas, Linda Dexlin Mellby.
The study was performed by Immunovia, Inc. in Marlborough, MA.
Poster: Commercial Test Model Study – A multicenter survey
Payam Delfani, Anders Carlsson, Thomas King, Randall Brand, Alexander Ney, Stephen P Pereira, A. James Moser, Genesis Perez-Melara, Corinne DeCicco, Alfredo Carrato, María E. Castillo-Sánchez, Julie Earl, Linda Dexlin Mellby
Acknowledgements: Immunovia would like to acknowledge, Diane M. Simone, MD, Director of the Pancreatic Cancer Center at NYU Langone’s Perlmutter Cancer Center, New York City, USA, Amy Lucas MD, Mount Sinai School of Medicine, New York City, USA and Växjö Central Hospital, Department of Transfusion Medicine, Sweden, for providing samples for the Commercial Test Model Study
The IMMray™ PanCan-d Commercial Test Model Study was finalized 2019.
Poster: Optimization Study – Differentiating pancreatic cancer from individuals with concerning symptoms, including type II diabetes
Payam Delfani, Anders Carlsson, Thomas King, Randall Brand, Alexander Ney, Stephen P Pereira, Linda Dexlin Mellby
The IMMray™ PanCan-d optimization study was finalized 2019.
The European Commission article on Immunovia’s IMMray PanCan-d test and the highly successful results of the Horizon 2020 IMMPACT project
Link to European Commission article.
More information about the Horizon 2020 project.
Poster presentation: Differentiating Pancreatic Ductal Adenocarcinoma (PDAC) from individuals with symptoms suggestive of PDAC, including type II diabetes, with ROC AUC values above 0.95
Payam Delfani, Anders Carlsson, Thomas King, Alexander Ney, Stephen P Pereira, Linda Dexlin Mellby
IMMray™ PanCan-d poster presentation at the PancreasFest 2019, Pittsburgh (PA), USA, July 24-26, 2019
Serum biomarker signature-based liquid biopsy for diagnosis of early-stage pancreatic cancer
Linda D. Mellby, Andreas P. Nyberg, Julia S. Johansen, Christer Wingren, Børge G. Nordestgaard, Stig E. Bojesen, Breeana L. Mitchell, Brett C. Sheppard, Rosalie C. Sears, and Carl A.K. Borrebaeck. J Clin Oncol. 2018 Aug; 36(28):2887-2894
Antibody microarray-based serum protein profiling of systemic lupus erythematosus and systemic sclerosis.
Carlsson, A., Wuttge, DM., Ingvarsson, J., Bengtsson, A., Sturfelt, G., Borrebaeck, CAK., and Wingren, C. Molecular and Cellular Proteomics, 2011, 10:M110.005033.
Precision diagnostics: moving towards protein biomarker signatures of clinical utility in cancer
Carl A. K. Borrebaeck. Nature Reviews Cancer (2017) doi:10.1038/nrc.2016.153. Published online 03 February 2017
Technical Advances of the Recombinant Antibody Microarray Technology Platform for Clinical Immunoproteomics
Payam Delfani, Linda Dexlin Mellby, Malin Nordström, Andreas Holmér, Mattias Ohlsson, Carl A. K. Borrebaeck, Christer Wingren. PLOS ONE. July 2016.
Antibody array generation and use
Borrebaeck, CAK, and Wingren C. Meth. Mol. Biol 2014, 1131, 563-57
Modelling the benefits of early diagnosis of pancreatic cancer using a biomarker signature
Ola Ghatnekar, Roland Andersson, Marianne Svensson, Ulf Persson, Ulrika Ringdahl, Paula Zeilon and Carl A.K. Borrebaeck
Intl Journal of Cancer 2013 (Abstract)
Serum proteome profiling of pancreatitis using recombinant antibody microarrays reveals disease-associated biomarker signatures.
Sandström A, Andersson R, Segersvärd R, Löhr M, Borrebaeck CAK, Wingren C
Proteomics – Clin Appl, 6:9-10, 486–496 (Abstract)
Design of recombinant antibody microarrays for urinary proteomics
Kristensson M, Olsson K, Carlson J, Wullt B, Sturfelt G, Borrebaeck CAK, Wingren, C. Proteomics – Clinical Applications, 2012, 6, 291-296.
Design of recombinant antibody microarrays for membrane protein profiling of cell lysates and tissue extracts.
Dexlin-Mellby, L., Sandström, A., Antberg, L., Karlsson, J., Hansson, SR., Borrebaeck, CAK., Wingren. C. Proteomics, 2011, 11, 1550-4.
Recombinant antibodies for the generation of arrays.
Borrebaeck, C.A.K. and Wingren, C. Meth. Mol. Biol.. 2011, 785, 247-62.
Design of recombinant antibody microarrays for complex proteome analysis: targeting of complement proteins.
Ingvarsson, J.; Larsson, A.; Sjöholm, L.; Truedsson, L.; Jansson, B.; Borrebaeck, C. A.K. and Wingren, C. J. Proteome Research. 2007, 6, 3527-3536.
Design of recombinant antibody microarrays for complex proteome analysis: choice of sample labelling-tag and solid support.
Wingren, C., Ingvarsson, J., Dexlin, L., Zul, D. and Borrebaeck, CAK. Proteomics. 2007, 7, 3055-3065.
High-throughput proteomics using antibody microarrays – an update.
Borrebaeck, C.A.K. and Wingren, C. Exp. Rew. Mol. Diagnostics. 2007, 7, 673-686.
Microarrays based on affinity-tagged scFv antibodies: sensitive detection of analyte in complex proteomes
Wingren, C., Steinhauer, C., Ingvarsson, J., Persson, E, Larsson, K., & Borrebaeck,C.A.K. Proteomics. 2005, 5:1281-1291.
High-throughput proteomics using antibody microarrays.
Wingren, C., Borrebaeck, C.A.K. Expert. Rew. Proteomics 2005, 1, 358-364.
Recombinant antibody microarrays: a viable option?
Wingren, C., Ingvarsson, J., Lindstedt, M., & Borrebaeck, C.A.K. Nature. Biotechnol. 2003, 21, 223.
Design of high-density antibody microarrays for disease proteomics: key technological issues.
Borrebaeck, C.A.K. and Wingren, C. J. Proteomics. 72, 928-935.
Poster presentation: Diagnosis of early stage pancreatic ductal adenocarcinoma using a serum biomarker signature
Linda D. Mellby, Andreas P. Holmér, Julia S. Johansen, Christer Wingren, Børge G. Nordestgaard, Stig E. Bojesen, Christopher Corless, Breanna I. Mitchell, Brett C. Sheppard, Rosalie C. Sears, och Carl A.K. Borrebaeck
IMMray™ PanCan-d poster presentation at the 49th Meeting Of The European Pancreas Club (EPC), Budapest, Hungary, June 28 – July 1 2017
Plasma protein profiling in a stage defined pancreatic cancer cohort – Implications for early diagnosis
Anna Sandström Gerdtsson, Christer Wingren, Helena Persson, Payam Delfani, Malin Nordström, He Ren, Xin Wen, Ulrika Ringdahl, Carl A.K. Borrebaeck, Jihui Hao. Molecular Oncology, 2016
Poster presentation: Early-stage diagnosis of pancreatic cancer offers opportunity to improve patient survival
Linda Mellby, Andreas Holmér, Julia S Johansen, Christer Wingren, Christopher Corless, Brett C Sheppard, Paige Rosenthal, Stig E Bojesen, Breanna L Mitchell, Børge G Nordestgaard, Rosalie Sears, and Carl AK Borrebaeck
IMMray™ PanCan-d poster presentation at the International Symposium on Pancreatic Cancer in Glasgow, UK, June 9-12 2016
A multicenter trial defining a serum protein signature associated with pancreatic ductal adenocarcinoma
Sandström Gerdtsson A, Malats N, Säll A, Real F, Porta M, Skoog P, Person H, Wingren C, Borrebaeck CAK. Int. J Proteomics. 2015
Serum protein profiling of pancreatitis using recombinant antibody microarrays reveals disease-associated biomarker signatures.
Sandström, A., Andersson, R., Segersvärd, R., Löhr, M., Borrebaeck, CAK., and Wingren C., Proteomics – Clinical Applications. 2012, 6, 486-496.
Identification of serum biomarker signatures associated with pancreatic cancer.
Wingren C, Sandström A, Segersvärd R, Carlsson A, Andersson R, Löhr M, Borrebaeck CAK Cancer Research, 2012, 72, 2481-2490.
Detection of pancreatic cancer using antibody microarray-based serum protein profiling.
Ingvarsson, J., Wingren, C., Carlsson, A., Ellmark, P., Wahren, B., Engström, G., Harmenberg, U., Krogh, M., Peterson, C., and Borrebaeck, C.A.K., Proteomics. 2008, 8, 2211-2219
Grading breast cancer tissues using molecular portraits.
Olsson, N., Carlsson, P., James, P., Hansson, K., Malmström, P., Fernö, M., Ryden, M., Wingren, C., and Borrebaeck, CAK., Mol. Cell. Proteomics. 2013, 12, 3612-3623.
Molecular serum portraits in patients with primary breast cancer predict the development of distant metastases.
Carlsson, A., Wingren, C., Kristensson, M., Fernö, M., Olsson, H., Peterson, C., Borrebaeck, CAK. Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 14252-7.
Serum proteome profiling of metastatic breast cancer using recombinant antibody microarrays.
Carlsson, A., Wingren, C., Ingvarsson, J., Ellmark, P., Baldertorp, B., Fernö, M., Olsson, H., and Borrebaeck, CAK. European Journal of Cancer. 2008, 44, 472-480.
Identification of plasma protein profiles associated with risk groups of prostate cancer patients.
Nordström M, Wingren C, Rose C, Bjartell A, Becker C, Lilja H, Borrebaeck CAK. Proteomics Clinical Applications, 2014, 8, 951-962.
Recombinant antibody microarray for profiling of the serum proteome of SLE.
Borrebaeck, CAK, Sturfelt G., and Wingren C. Meth. Mol. Biol 2014, 1134, 67-78.
Multiplexing of miniaturized planar antibody arrays for serum protein profiling – biomarker discovery in SLE nephritis.
Petersson L, Dexlin-Mellby, L., Bengtsson, A.A., Sturfelt, G., Borrebaeck CAK, Wingren C. Lab on a chip. 2014, 14, 1931-1942.
Design of recombinant antibody microarrays for urinary proteomics
Kristensson M, Olsson K, Carlson J, Wullt B, Sturfelt G, Borrebaeck CAK, Wingren, C. Proteomics Clinical Applications, 2012, 6, 291-296.
