Precision diagnostics: moving towards protein biomarker signatures of clinical utility in cancer

Carl A. K. Borrebaeck. Nature Reviews Cancer (2017) doi:10.1038/nrc.2016.153. Published online 03 February 2017

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Technical Advances of the Recombinant Antibody Microarray Technology Platform for Clinical Immunoproteomics

Payam Delfani, Linda Dexlin Mellby, Malin Nordström, Andreas Holmér, Mattias Ohlsson, Carl A. K. Borrebaeck, Christer Wingren. PLOS ONE. July 2016.

Antibody array generation and use.

Borrebaeck, CAK, and Wingren C. Meth. Mol. Biol 2014, 1131, 563-571.

Modelling the benefits of early diagnosis of pancreatic cancer using a biomarker signature

Ola Ghatnekar, Roland Andersson, Marianne Svensson, Ulf Persson, Ulrika Ringdahl, Paula Zeilon and Carl A.K. Borrebaeck
Intl Journal of Cancer 2013 (Abstract)

Serum proteome profiling of pancreatitis using recombinant antibody microarrays reveals disease-associated biomarker signatures.

Sandström A, Andersson R, Segersvärd R, Löhr M, Borrebaeck CAK, Wingren C
Proteomics – Clin Appl, 6:9-10, 486–496 (Abstract)

Design of recombinant antibody microarrays for urinary proteomics

Kristensson M, Olsson K, Carlson J, Wullt B, Sturfelt G, Borrebaeck CAK, Wingren, C. Proteomics – Clinical Applications, 2012, 6, 291-296.

Design of recombinant antibody microarrays for membrane protein profiling of cell lysates and tissue extracts.

Dexlin-Mellby, L., Sandström, A., Antberg, L., Karlsson, J., Hansson, SR., Borrebaeck, CAK., Wingren. C.  Proteomics, 2011, 11, 1550-4.

Recombinant antibodies for the generation of arrays.

Borrebaeck, C.A.K. and Wingren, C. Meth. Mol. Biol.. 2011, 785, 247-62.

Design of recombinant antibody microarrays for complex proteome analysis: targeting of complement proteins.

Ingvarsson, J.; Larsson, A.; Sjöholm, L.; Truedsson, L.; Jansson, B.; Borrebaeck, C. A.K. and Wingren, C.  J. Proteome Research. 2007, 6, 3527-3536.

Design of recombinant antibody microarrays for complex proteome analysis: choice of sample labelling-tag and solid support.

Wingren, C., Ingvarsson, J., Dexlin, L., Zul, D. and Borrebaeck, CAK.  Proteomics. 2007, 7, 3055-3065.

High-throughput proteomics using antibody microarrays – an update.

Borrebaeck, C.A.K. and Wingren, C. Exp. Rew. Mol. Diagnostics. 2007, 7, 673-686.

Microarrays based on affinity-tagged scFv antibodies: sensitive detection of analyte in complex proteomes

Wingren, C., Steinhauer, C., Ingvarsson, J., Persson, E, Larsson, K., & Borrebaeck,C.A.K. Proteomics. 2005, 5:1281-1291.

High-throughput proteomics using antibody microarrays.

Wingren, C., Borrebaeck, C.A.K.  Expert. Rew. Proteomics 2005, 1, 358-364.

Recombinant antibody microarrays: a viable option ?

Wingren, C., Ingvarsson, J., Lindstedt, M., & Borrebaeck, C.A.K. Nature. Biotechnol. 2003, 21, 223.

Design of high-density antibody microarrays for disease proteomics: key technological issues.

Borrebaeck, C.A.K. and Wingren, C.  J. Proteomics. 72, 928-935.